2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-133327
    Amino-PEG12-amine 361543-12-6 99.92%
    Amino-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG12-amine
  • HY-W003511
    tans-4-Hydroxy-D-proline hydrochloride 142347-81-7
    tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR
    tans-4-Hydroxy-D-proline hydrochloride
  • HY-W040228
    BnO-PEG4-OH 86259-87-2 98.82%
    BnO-PEG4-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    BnO-PEG4-OH
  • HY-140190
    Amino-PEG2-(CH2)3COOH 1263046-77-0
    Amino-PEG2-(CH2)3COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG2-(CH2)3COOH
  • HY-140730
    Thiol-PEG-CH2COOH (MW 5000)
    Thiol-PEG-CH2COOH (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG-CH2COOH (MW 5000)
  • HY-119343
    Biotin-PFP ester 120550-35-8
    Biotin-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PFP ester
  • HY-140882
    Boc-NH-PEG7-propargyl 2112737-90-1
    Boc-NH-PEG7-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG7-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Boc-NH-PEG7-propargyl
  • HY-140954
    DSPE-PEG5-azide 2112737-73-0
    DSPE-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DSPE-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    DSPE-PEG5-azide
  • HY-140485
    Acid-PEG5-mono-methyl ester 1309460-30-7 98.0%
    Acid-PEG5-mono-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG5-mono-methyl ester
  • HY-140832
    m-PEG24-azide 2563873-82-3
    m-PEG24-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG24-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG24-azide
  • HY-130388
    Propargyl-PEG5-NHS ester 1393330-40-9 98.0%
    Propargyl-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG5-NHS ester
  • HY-140543
    N-DBCO-N-bis(PEG2-C2-acid) 2110449-00-6
    N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-DBCO-N-bis(PEG2-C2-acid) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    N-DBCO-N-bis(PEG2-C2-acid)
  • HY-140731
    TCO-PEG-TCO (MW 5000)
    TCO-PEG-TCO (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-PEG-TCO (MW 5000) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-PEG-TCO (MW 5000)
  • HY-130142A
    Biotinyl-NH-PEG3-C3-amido-C3-COOH 1202761-21-4 99.25%
    Biotinyl-NH-PEG3-C3-amido-C3-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotinyl-NH-PEG3-C3-amido-C3-COOH
  • HY-140037
    Mal-​PEG4-​propargyl 1262681-30-0 99.68%
    Mal-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Mal-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Mal-​PEG4-​propargyl
  • HY-133406
    exo BCN-O-PNB 1380006-72-3 98.0%
    exo BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. exo BCN-O-PNB is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    exo BCN-O-PNB
  • HY-120175
    Nonaethylene glycol monomethyl ether 6048-68-6
    Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Nonaethylene glycol monomethyl ether
  • HY-40151
    Methyl 1-Boc-azetidine-3-carboxylate 610791-05-4 99.89%
    Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
    Methyl 1-Boc-azetidine-3-carboxylate
  • HY-122696
    CH2COOH-PEG3-CH2COOH 32775-08-9 99.06%
    CH2COOH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    CH2COOH-PEG3-CH2COOH
  • HY-133472
    DBCO-NHCO-PEG3-Fmoc
    DBCO-NHCO-PEG3-Fmoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG3-Fmoc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG3-Fmoc
PROTAC Linkers Isoform Comparison

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